Does Skin + Case Work?

Does anyone know if I can use both a Dbrand/ SlickWraps skin (seem like the best 2 choices) & a Spigen case (going for the Tough Armor) without any interference between them? I really like the look of the bare Panda/ Penguin 2 XL, but I would also like to have a nice skin on it. I'm kind of a clumsy person, so I plan on getting a case no matter what (maybe Spigen if the reviews are good), but I'm not sure if I can use both a skin & case together without a problem. I want to make sure the money I spend on a skin isn't going to waste. This is my first time with Spigen cases & Dbrand/ SlickWraps skins, so any & all advice would also be appreciated.