Why does acid make me emotionally overwhelmed / depressed the days after when other substances dont

I've done MDMA and 2cb a handful of times and I don't really have a emotional crash the days after (since theyre "similar"). These and other substances can leave me drained/fried for a bit or I'll even have a good afterwards but I'm more or less myself and can go about daily life. I've tried acid from a range of 50-200ug and it always makes me depressed and irritable the next day. The though of cleaning my room, cooking, or any simple task feels overwhelming and my temper is really bad.