What are some future social/wedge issues that will come about when the current crop is settled?

I've seen a lot of discussion lately as to whether or not all social issues will inevitably end with the liberal stance. While I don't think this is the case, it got me thinking about what some potential future social issues are on the horizon when the issues of the Drug War, the death penalty, and LGBTQ rights, for example, are settled. I can see genetically modified children being a major issue, with reactionaries seeing it as unnatural.