The Scientist and their Supernatural Buddy
They don't need to specifically be involved in the sciences, or an expert in the supernatural. As long as the contrast between the two is highlighted in their dynamics. Bonus Points if they're dating.
- **Dana Scully & Fox Mulder** from *X-Files*: Dana is a Forensic Pathologist, paired together with Fox Mulder, who is an FBI agent dealing with supernatural cases. He is often positioned as a conspiracy theorist, though his theories almost always end up being correct. They are dating.
- **Agnes Tachyon & Manhattan Cafe** from the *Uma Musume* franchise: Tachyon is a scientist experimenting on horsegirl physiology. She has a particular interest in her friend Cafe, who has an "imaginary friend" that appears to be very much real *and* a literal ghost. They might be dating, unconfirmed (Jungle Pocket is involved somehow too).
- **The Winchesters & Castiel** from *Supernatural*: Sam and Dean Winchester are brothers, fighting supernatural creatures and returning them to whence they came, with their experience and expertise and the lore they have from their Father's diary. Castiel, as suggested by the name, is a literal Angel, who assists the two throughout the show after God decides he was done with humanity. We sure love shipping Dean and Castiel but then Cass got sent to homophobic super-hell so...