A main character is an outlier for their species/race/universe/etc.

Shrek is actually smaller than average for an ogre and the other ogres make fun of him for it.- Shrek Forever After(2010)

Taz has a family who all wear clothes and shoes, speak normally, and have human intelligence- Taz-Mania (1991)

Mark Grayson of the main universe is one of the few if only good Invincibles across the multiverse- Invincible.