So we all joke about the Metal Gear Series not knowing shit about genetics in its narrative but what are some examples of games that do? And that do interesting things with them?

I've been watching some reactions to the final codec call in MGS2 and while that's aged quite well as a distillation of ideas regarding the future of the internet at the time, I'm reminded that the ending of the first game didn't age so gracefully. Liquid is just wrong about everything regarding genetics, in fact I think most characters are.