Linzess Question

IBS-C diagnosis to start the conversation. Been struggling for my whole life with constipation. I am an RN and have tried alllll the interventions I know: I drink 3-4 liters of water per day, 6 tsp benefiber per day, I have removed dairy (it seems to just stop my gut all together when I do consume dairy- still weeding out trigger foods), had a new appointment with a new GI doc that was awesome. I’ve had a positive Celiac blood test, negative biopsy- obtained blood work for the HLAs. She axed the Miralax and docusate and PRN senna and said here take this….Linzess. I’m on the lowest dose.

Wow, this stuff was like heaven! Take in the morning and like a good little soldier it pulled the water I drown myself in daily and I’d have a movement and be super awesome for the day. Didn’t change anything about my routine, other than getting rid of the meds that she wanted me to and replace with the Linzess.

So I’m three months down the line and it isn’t ✨WOrKIng✨anymore!!!!!! I am taking it exactly how I have been and I am so constipated I have to work hard again to get a movement out and the worst part about this is…right as I started seeing this new GI doc my pelvic floor collapsed. I can’t “work” to get anything out. I’m in constant spasm and have a damned of a time moving my bowels period. So constipation is not ideal right now. And the pelvic floor center I am going to can’t see me til APRIL 🤦🏻‍♀️

So my question is has anyone experienced this? Linzess just not working anymore? Wait it out? Increase water even more? Thank you so much for any answers!!!! I appreciate your time!