Is it possible to use one monitor with a mouse while playing a game on another monitor with a remote at the same time?

So say i have one PC with two monitors, could I set it up so that I can play a game with an Xbox PC remote on one monitor while browsing the internet on the other monitor with a mouse at the same time? Do I need special hardware or anything to do it, or is it just impossible? Sorry if this is the wrong subreddit I wasn't sure where else to ask this question.