Programs don't start after a while of PC running

Heya! I recently had the issue occur on the regular after some use of my PC, approx. half an hour.

I first thought it would be a RAM issue, so I did diagnostics and all, didn't find a problem, still tried changing the RAM to two new sticks. Then also tried two different slots, but nothing helped. Even several scans and all, nothing seems to be defect, infected or broken otherwise.

So after checking my drivers and all, I decided to make a clean windows install, which I did, but again, the problem happens.

Running apps are working fine, even games run properly, just can't launch them, only thing that I can't do is install something while that happens as the install just won't work.

I did get a BSOD while gaming that posted the System Thread Exception Not Handled earlier, but that's the first time I had that.

Restarting does fix the problem, but I really don't want to restart every couple of hours.

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I'm kind of out of ideas and would appreciate some help, thank you in advance!