Cool Whine or Slow Startup

I've posted a couple days ago asking about a noisy PSU that emits a Cool Whine only under low load (https://www.reddit.com/r/techsupport/comments/8kaesf/noise_coming_from_psu_only_under_low_cpu_usage/). I've found the solution (disable Global C-States on Bios) but if I do that I get a major slowdown at startup. It normalizes after about one minute, but it's bad. I heard that I can stop this noise disabling only C1E, but I can't find the option to disable only this on my Bios (MOBO Gigabyte AX370).

I'm under the impression that my PC runs worse with Global C-States disabled, even if it's not as bad as during startup. Can disabling Global C-States really makes my PC runs slower? If so, currently I have to choose between annoying noise and slow PC.

I'm having other issues, not sure if related to Cool Whine. With or without C-States, I think my USB ports aren't getting powered properly. My wireless mouse stutters from times to times and it never happened before with my old build (I had to rebuild my PC with new MOBO/RAM/CPU and old GPU/PSU). I think it's worse when a external HD is connected, but still lags without it.

My specs:

CPU: AMD Ryzen 5 1400

RAM: 8 GB Corsair DDR4

MOBO: Gigabyte AX370

PSU: Corsair CX 750

Wireless Mouse: Logitech M280

GPU: Radeon HD 7950 3Gb.