Has anyone created a Rogue-like playthru?

I'm wanting to try a different way of playing the game and thought a rogue-like play through would be fun if possible.Has anyone done something like this with mods or self made rules somehow? I'm not quite sure how it would work as normal mode is 'kinda' like one already. I think something like epic loot would be involved to keep each life interesting probably. Any ideas welcome.