What Lore is Important?

Hey yall,

So i am a long time DM for D&D, and with the new Dimension 20 show that came out i became fascinated with WOD and primarily VTM. I want to run a chronical for my main table the next time its my turn, and the players seem into it. We live in the twin cities and I found out that the Camarilla supposedly has control here, so I was wondering what lore is actually necessary for a first time ST? I found a few videos on the clans, and even began watching a few chronicals by some YouTubers to get a better idea then how BLM runs his games. But im getting overwhelmed at this time woth how much lore there is, and unlike D&D I cant just make up a random nation or city, and I feel weird removing an entire camarilla for my own kindred to rule in the story.

So yeah, any help with necessary lore would be great! And im planning to run a game set in our home of the twin cities.