Ever had a whiskey taste terrible when mixed?

I bought a bottle of Rye whiskey that tastes absolutely disgusting and undrinkable, but only when mixed.

When I first opened the bottle I shared some with my friends and we all had a pour to taste it. It was fine, nothing remarkable, but totally drinkable. Then some time later I used it in an old fashioned that was horrible. But having had the whiskey straight before, I assumed it was the bitters or the preserved cherry I used that had gone bad, so I dumped it and made a different drink. Then last week I made a bourbon and ginger ale with the same rye whiskey, undrinkable, had to pour it out. Poured some neat, and it was fine.

But mixed it tastes like a moldy leather boot. Like absolutely disgusting. Like your body is rejecting this as “spoiled” and won’t let you drink it.

Anybody ever had a whiskey that tastes worse when mixed? Any idea what would cause that?